Endogenous retrovirus group K member 6 Rec protein

Definition:

Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts.

References:

[1]. J Yang, et al. The human endogenous retrovirus K Rev response element coincides with a predicted RNA folding region. RNA. 2000 Nov;6(11):1551-64. [Content Brief]

[2]. C Magin, et al. cORF and RcRE, the Rev/Rex and RRE/RxRE homologues of the human endogenous retrovirus family HTDV/HERV-K. J Virol. 1999 Nov;73(11):9496-507. [Content Brief]

[3]. H P Bogerd, et al. Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K. J Virol. 2000 Oct;74(20):9353-61. [Content Brief]

[4]. J Yang, et al. An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein. Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13404-8. [Content Brief]

[5]. A Boese, et al. Human endogenous retrovirus protein cORF supports cell transformation and associates with the promyelocytic leukemia zinc finger protein. Oncogene. 2000 Sep 7;19(38):4328-36. [Content Brief]

[6]. C Magin-Lachmann, et al. Rec (formerly Corf) function requires interaction with a complex, folded RNA structure within its responsive element rather than binding to a discrete specific binding site. J Virol. 2001 Nov;75(21):10359-71. [Content Brief]

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