Enlarged parietal foramina/cranium bifidum

Definition:

Enlarged parietal foramina/cranium bifidum is characterised by oval defects in the parietal bones. It results from incomplete ossification of the parietal bones during development and is caused by ALX4 or MSX2 gene mutations.

References:

[1]. T O Bello, et al. Foramina parietalia permagna in a Nigerian family. West Afr J Med. 2009 May;28(3):182-4. [Content Brief]

[2]. W Wuyts, et al. The ALX4 homeobox gene is mutated in patients with ossification defects of the skull (foramina parietalia permagna, OMIM 168500). J Med Genet. 2000 Dec;37(12):916-20. [Content Brief]

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