EP300-interacting inhibitor of differentiation 2

Definition

Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex.

References:

[1]. Ho-Jae Lee, et al. A novel E1A-like inhibitor of differentiation (EID) family member, EID-2, suppresses transforming growth factor (TGF)-beta signaling by blocking TGF-beta-induced formation of Smad3-Smad4 complexes. J Biol Chem. 2004 Jan 23;279(4):2666-72. [Content Brief]

[2]. Aimin Ji, et al. EID-2, a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoD. Gene. 2003 Oct 30;318:35-43. [Content Brief]

[3]. Satoshi Miyake, et al. A novel EID-1 family member, EID-2, associates with histone deacetylases and inhibits muscle differentiation. J Biol Chem. 2003 May 9;278(19):17060-5. [Content Brief]

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