Epidermal growth factor receptor substrate 15-like 1

Definition:

Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.

References:

[1]. R Carbone, et al. eps15 and eps15R are essential components of the endocytic pathway. Cancer Res. 1997 Dec 15;57(24):5498-504. [Content Brief]

[2]. Anjali Teckchandani, et al. The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin β1 endocytosis. Mol Biol Cell. 2012 Aug;23(15):2905-16. [Content Brief]

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