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Essential MCU regulator, mitochondrial

Definition:

Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU. Plays a central role in regulating the uniplex complex response to intracellular calcium signaling. Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling.

References:

[1]. Yasemin Sancak, et al. EMRE is an essential component of the mitochondrial calcium uniporter complex. Science. 2013 Dec 13;342(6164):1379-82. [Content Brief]

[2]. Ming-Feng Tsai, et al. Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex. Elife. 2016 Apr 21;5:e15545. [Content Brief]

[3]. Horia Vais, et al. EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter. Cell Rep. 2016 Jan 26;14(3):403-410. [Content Brief]

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