ETS translocation variant 3

Definition:

Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.

References:

[1]. Günter W Klappacher, et al. An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Cell. 2002 Apr 19;109(2):169-80. [Content Brief]

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