Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

Definition:

Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

References:

[1]. C G Jakobsen, et al. [Identification of a novel termination release factor eRF3b expressing the eRF3 activity in vitro and in vivo]. Mol Biol (Mosk). 2001 Jul-Aug;35(4):672-81. [Content Brief]

[2]. Céline Chauvin, et al. Human eukaryotic release factor 3a depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway. Mol Cell Biol. 2007 Aug;27(16):5619-29. [Content Brief]

[3]. Céline Chauvin, et al. Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation. Mol Cell Biol. 2005 Jul;25(14):5801-11. [Content Brief]

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