Eukaryotic translation initiation factor 2A

Definition:

Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

References:

[1]. Wendy L Zoll, et al. Characterization of mammalian eIF2A and identification of the yeast homolog. J Biol Chem. 2002 Oct 4;277(40):37079-87. [Content Brief]

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