Exopolyphosphatase PRUNE1

Definition:

Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization.

References:

[1]. A Reymond, et al. Evidence for interaction between human PRUNE and nm23-H1 NDPKinase. Oncogene. 1999 Dec 2;18(51):7244-52. [Content Brief]

[2]. Anna D'Angelo, et al. Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis. Cancer Cell. 2004 Feb;5(2):137-49. [Content Brief]

[3]. L Garzia, et al. Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility. Oncogene. 2008 Mar 20;27(13):1853-64. [Content Brief]

[4]. Tsuyoshi Kobayashi, et al. Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions. Mol Cell Biol. 2006 Feb;26(3):898-911. [Content Brief]

[5]. Massimo Zollo, et al. PRUNE is crucial for normal brain development and mutated in microcephaly with neurodevelopmental impairment. Brain. 2017 Apr 1;140(4):940-952. [Content Brief]

[6]. A Forus, et al. Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas-a possible mechanism for altering the nm23-H1 activity. Oncogene. 2001 Oct 18;20(47):6881-90. [Content Brief]

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