[F-actin]-monooxygenase MICAL2

Definition:

Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.

References:

[1]. Mark R Lundquist, et al. Redox modification of nuclear actin by MICAL-2 regulates SRF signaling. Cell. 2014 Jan 30;156(3):563-76. [Content Brief]

[2]. Heng Wu, et al. The MICALs are a Family of F-actin Dismantling Oxidoreductases Conserved from Drosophila to Humans. Sci Rep. 2018 Jan 17;8(1):937. [Content Brief]

[3]. Chiara Galloni, et al. MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes. J Cell Biol. 2021 Aug 2;220(8):e202102043. [Content Brief]

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