F-box/LRR-repeat protein 14

Definition:

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1.

References:

[1]. Rosa Viñas-Castells, et al. The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation. J Biol Chem. 2010 Feb 5;285(6):3794-3805. [Content Brief]

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