F-box/SPRY domain-containing protein 1

Definition:

Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation.

References:

[1]. A Peschiaroli, et al. The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73. Oncogene. 2009 Sep 3;28(35):3157-66. [Content Brief]

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