Familial advanced sleep phase syndrome

Definition:

Familial advanced sleep phase syndrome (FASPS) is characterized by a stable sleep schedule with a 4-hour advance than the conventional or desired time. FASPS is associated with mutations in PER2, whose level oscillates with a nearly 24 hour period. Recently, it has been reported that FASPS is also caused by mutations in CSNK1D gene and PER3 gene.

References:

[1]. Ana Barion, et al. Circadian rhythm sleep disorders. Dis Mon. 2011 Aug;57(8):423-37. [Content Brief]

[2]. Bjørn Bjorvatn, et al. A practical approach to circadian rhythm sleep disorders. Sleep Med Rev. 2009 Feb;13(1):47-60. [Content Brief]

[3]. C R Jones, et al. Familial advanced sleep-phase syndrome: A short-period circadian rhythm variant in humans. Nat Med. 1999 Sep;5(9):1062-5. [Content Brief]

[4]. K C Brennan, et al. Casein kinase iδ mutations in familial migraine and advanced sleep phase. Sci Transl Med. 2013 May 1;5(183):183ra56, 1-11. [Content Brief]

[5]. K L Toh, et al. An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science. 2001 Feb 9;291(5506):1040-3. [Content Brief]

[6]. Luoying Zhang, et al. A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1536-44. [Content Brief]

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