Farnesyltransferase (FTase)

Definition:

Farnesyltransferase (FTase) is a two-subunits heterodimeric zinc enzyme that is comprised by a 48 kDa a-subunit and a 46 kDa ß-subuni. Farnesyltransferase (FTase) is a major molecular target for the development of novel anticancer drugs that are designed to disrupt the aberrant signal transduction circuitry of tumor cells.

References:

[1]. Kuichun Zhu, et al. Farnesyltransferase inhibitors as anticancer agents: current status. Curr Opin Investig Drugs. 2003 Dec;4(12):1428-35. [Content Brief]

[2]. Sérgio F Sousa, et al. Farnesyltransferase inhibitors: a detailed chemical view on an elusive biological problem. Curr Med Chem. 2008;15(15):1478-92. [Content Brief]

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