FAS-associated factor 1

Definition:

Ubiquitin-binding protein. Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation. Potentiates but cannot initiate FAS-induced apoptosis (By similarity).

References:

[1]. Jinsue Song, et al. Structure and interaction of ubiquitin-associated domain of human Fas-associated factor 1. Protein Sci. 2009 Nov;18(11):2265-76. [Content Brief]

[2]. André Franz, et al. Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun. 2016 Feb 4;7:10612. [Content Brief]

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