Fascin

Definition:

Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF.

References:

[1]. Silvia Jansen, et al. Mechanism of actin filament bundling by fascin. J Biol Chem. 2011 Aug 26;286(34):30087-96. [Content Brief]

[2]. Lin Chen, et al. Migrastatin analogues target fascin to block tumour metastasis. Nature. 2010 Apr 15;464(7291):1062-6. [Content Brief]

[3]. Shengyu Yang, et al. Molecular mechanism of fascin function in filopodial formation. J Biol Chem. 2013 Jan 4;288(1):274-84. [Content Brief]

[4]. Katrin Deinhardt, et al. Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac. Sci Signal. 2011 Dec 6;4(202):ra82. [Content Brief]

[5]. J C Adams, et al. Characterization of cell-matrix adhesion requirements for the formation of fascin microspikes. Mol Biol Cell. 1997 Nov;8(11):2345-63. [Content Brief]

[6]. Ang Li, et al. The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion. Curr Biol. 2010 Feb 23;20(4):339-45. [Content Brief]

[7]. S Yamashiro, et al. Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells. Mol Biol Cell. 1998 May;9(5):993-1006. [Content Brief]

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