FAST kinase domain-containing protein 2, mitochondrial

Definition:

Plays an important role in assembly of the mitochondrial large ribosomal subunit. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. May play a role in mitochondrial apoptosis.

References:

[1]. Johannes Popow, et al. FASTKD2 is an RNA-binding protein required for mitochondrial RNA processing and translation. RNA. 2015 Nov;21(11):1873-84. [Content Brief]

[2]. Jason D Arroyo, et al. A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation. Cell Metab. 2016 Dec 13;24(6):875-885. [Content Brief]

[3]. Hana Antonicka, et al. Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis. Cell Rep. 2015 Feb 17;10(6):920-932. [Content Brief]

[4]. Daniele Ghezzi, et al. FASTKD2 nonsense mutation in an infantile mitochondrial encephalomyopathy associated with cytochrome c oxidase deficiency. Am J Hum Genet. 2008 Sep;83(3):415-23. [Content Brief]

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