Feline leukemia virus subgroup C receptor-related protein 1

Definition:

[Isoform 1]: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. Causes susceptibility to FeLV-C in vitro.; [Isoform 2]: Heme transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation.

References:

[1]. John G Quigley, et al. Identification of a human heme exporter that is essential for erythropoiesis. Cell. 2004 Sep 17;118(6):757-66. [Content Brief]

[2]. Deborah Chiabrando, et al. Mutations in the Heme Exporter FLVCR1 Cause Sensory Neurodegeneration with Loss of Pain Perception. PLoS Genet. 2016 Dec 6;12(12):e1006461. [Content Brief]

[3]. C S Tailor, et al. A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily. J Virol. 1999 Aug;73(8):6500-5. [Content Brief]

[4]. Zhantao Yang, et al. Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin. J Biol Chem. 2010 Sep 10;285(37):28874-82. [Content Brief]

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