FERM domain-containing protein 8

Definition:

Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface. Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6.

References:

[1]. Lorna S Kategaya, et al. Bili inhibits Wnt/beta-catenin signaling by regulating the recruitment of axin to LRP6. PLoS One. 2009 Jul 2;4(7):e6129. [Content Brief]

[2]. Ioanna Oikonomidi, et al. iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE. Elife. 2018 Jun 13;7:e35032. [Content Brief]

[3]. Ulrike Künzel, et al. FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex. Elife. 2018 Jun 13;7:e35012. [Content Brief]

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