Fetal and adult testis-expressed transcript protein

Definition:

Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis. May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling.

References:

[1]. Mabrouka Doghman-Bouguerra, et al. FATE1 antagonizes calcium- and drug-induced apoptosis by uncoupling ER and mitochondria. EMBO Rep. 2016 Sep;17(9):1264-80. [Content Brief]

[2]. Kimberly E Maxfield, et al. Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer. Nat Commun. 2015 Nov 16;6:8840. [Content Brief]

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