FH1/FH2 domain-containing protein 1

Definition:

Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.

References:

[1]. Judith E Gasteier, et al. FHOD1 coordinates actin filament and microtubule alignment to mediate cell elongation. Exp Cell Res. 2005 May 15;306(1):192-202. [Content Brief]

[2]. Sebastian Hannemann, et al. The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing. J Biol Chem. 2008 Oct 10;283(41):27891-27903. [Content Brief]

[3]. Ryu Takeya, et al. Fhos, a mammalian formin, directly binds to F-actin via a region N-terminal to the FH1 domain and forms a homotypic complex via the FH2 domain to promote actin fiber formation. J Cell Sci. 2003 Nov 15;116(Pt 22):4567-75. [Content Brief]

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