FH2 domain-containing protein 1

Definition:

Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation. Regulates Golgi ribbon formation. Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly.

References:

[1]. Kevin G Young, et al. INF1 is a novel microtubule-associated formin. Mol Biol Cell. 2008 Dec;19(12):5168-80. [Content Brief]

[2]. Sarah J Copeland, et al. Actin- and microtubule-dependent regulation of Golgi morphology by FHDC1. Mol Biol Cell. 2016 Jan 15;27(2):260-76. [Content Brief]

[3]. Sarah J Copeland, et al. Actin-dependent regulation of cilia length by the inverted formin FHDC1. Mol Biol Cell. 2018 Jul 1;29(13):1611-1627. [Content Brief]

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