Fibrinogen C domain-containing protein 1

Definition:

Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components.

References:

[1]. Anders Schlosser, et al. Characterization of FIBCD1 as an acetyl group-binding receptor that binds chitin. J Immunol. 2009 Sep 15;183(6):3800-9. [Content Brief]

[2]. Theresa Thomsen, et al. The recognition unit of FIBCD1 organizes into a noncovalently linked tetrameric structure and uses a hydrophobic funnel (S1) for acetyl group recognition. J Biol Chem. 2010 Jan 8;285(2):1229-38. [Content Brief]

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