Fibroblast growth factor 21

Definition:

Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity.

References:

[1]. Alexei Kharitonenkov, et al. FGF-21 as a novel metabolic regulator. J Clin Invest. 2005 Jun;115(6):1627-35. [Content Brief]

[2]. Hiroshi Kurosu, et al. Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J Biol Chem. 2007 Sep 14;282(37):26687-26695. [Content Brief]

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