Fibroblast growth factor 8

Definition:

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells.

References:

[1]. D M Ornitz, et al. Receptor specificity of the fibroblast growth factor family. J Biol Chem. 1996 Jun 21;271(25):15292-7. [Content Brief]

[2]. Chiara Vantaggiato, et al. Senataxin modulates neurite growth through fibroblast growth factor 8 signalling. Brain. 2011 Jun;134(Pt 6):1808-28. [Content Brief]

[3]. Xiuqin Zhang, et al. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J Biol Chem. 2006 Jun 9;281(23):15694-700. [Content Brief]

[4]. Shaun K Olsen, et al. Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain. Genes Dev. 2006 Jan 15;20(2):185-98. [Content Brief]

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