Filaggrin-2

Definition:

Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis.

References:

[1]. Maria C Bolling, et al. Generalized Ichthyotic Peeling Skin Syndrome due to FLG2 Mutations. J Invest Dermatol. 2018 Aug;138(8):1881-1884. [Content Brief]

[2]. Janan Mohamad, et al. Filaggrin 2 Deficiency Results in Abnormal Cell-Cell Adhesion in the Cornified Cell Layers and Causes Peeling Skin Syndrome Type A. J Invest Dermatol. 2018 Aug;138(8):1736-1743. [Content Brief]

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