Filamin-binding LIM protein 1

Definition:

Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion.

References:

[1]. Sujay Subbayya Ithychanda, et al. Migfilin, a molecular switch in regulation of integrin activation. J Biol Chem. 2009 Feb 13;284(7):4713-22. [Content Brief]

[2]. Toshiro Takafuta, et al. A new member of the LIM protein family binds to filamin B and localizes at stress fibers. J Biol Chem. 2003 Apr 4;278(14):12175-81. [Content Brief]

[3]. Yatish Lad, et al. Structural basis of the migfilin-filamin interaction and competition with integrin beta tails. J Biol Chem. 2008 Dec 12;283(50):35154-63. [Content Brief]

[4]. Yizeng Tu, et al. Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. Cell. 2003 Apr 4;113(1):37-47. [Content Brief]

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