FLYWCH-type zinc finger-containing protein 1

Definition:

Transcription cofactor. Negatively regulates transcription activation by catenin beta-1 CTNNB1, perhaps acting by competing with TCF4 for CTNNB1 binding. May play a role in DNA-damage response signaling. Binds specifically to DNA sequences at peri-centromeric chromatin loci.

References:

[1]. Irene Santos-Barriopedro, et al. Off-the-shelf proximity biotinylation for interaction proteomics. Nat Commun. 2021 Aug 18;12(1):5015. [Content Brief]

[2]. Sheema Almozyan, et al. FLYWCH1, a Multi-Functional Zinc Finger Protein Contributes to the DNA Repair Pathway. Cells. 2021 Apr 13;10(4):889. [Content Brief]

[3]. Belal A Muhammad, et al. FLYWCH1, a Novel Suppressor of Nuclear β-Catenin, Regulates Migration and Morphology in Colorectal Cancer. Mol Cancer Res. 2018 Dec;16(12):1977-1990. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.