Follitropin subunit beta

Definition:

Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs.

References:

[1]. G B Maroulis, et al. Isolated follicle-stimulating hormone deficiency in man. Fertil Steril. 1977 Aug;28(8):818-22. [Content Brief]

[2]. Xuliang Jiang, et al. Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer. J Biol Chem. 2014 May 16;289(20):14273-82. [Content Brief]

[3]. J L Keene, et al. Expression of biologically active human follitropin in Chinese hamster ovary cells. J Biol Chem. 1989 Mar 25;264(9):4769-75. [Content Brief]

[4]. C H Matthews, et al. Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone. Nat Genet. 1993 Sep;5(1):83-6. [Content Brief]

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