Forkhead box protein C1
Definition:
References:
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[1]. Yoko A Ito, et al. Analyses of a novel L130F missense mutation in FOXC1. Arch Ophthalmol. 2007 Jan;125(1):128-35. [Content Brief]
[2]. Lianghua Bin, et al. Forkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation. PLoS One. 2016 Dec 1;11(12):e0167392. [Content Brief]
[3]. Bingchen Han, et al. FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer. Cell Rep. 2015 Nov 3;13(5):1046-58. [Content Brief]
[4]. Yoko A Ito, et al. Severe molecular defects of a novel FOXC1 W152G mutation result in aniridia. Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3573-9. [Content Brief]
[5]. R A Saleem, et al. Essential structural and functional determinants within the forkhead domain of FOXC1. Nucleic Acids Res. 2004 Aug 6;32(14):4182-93. [Content Brief]
[6]. Fred B Berry, et al. FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner. Mol Cell Biol. 2005 Feb;25(4):1415-24. [Content Brief]
[7]. Ramsey A Saleem, et al. Identification and analysis of a novel mutation in the FOXC1 forkhead domain. Invest Ophthalmol Vis Sci. 2003 Nov;44(11):4608-12. [Content Brief]
[8]. S Pierrou, et al. Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. EMBO J. 1994 Oct 17;13(20):5002-12. [Content Brief]
[9]. Partha S Ray, et al. FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer. Cancer Res. 2010 May 15;70(10):3870-6. [Content Brief]
[10]. Yong Zhou, et al. Identification of FOXC1 as a TGF-beta1 responsive gene and its involvement in negative regulation of cell growth. Genomics. 2002 Nov;80(5):465-72. [Content Brief]
[11]. C D Fetterman, et al. Characterization of a novel FOXC1 mutation, P297S, identified in two individuals with anterior segment dysgenesis. Clin Genet. 2009 Sep;76(3):296-9. [Content Brief]
[12]. Hiroyuki Yamagishi, et al. Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer. Genes Dev. 2003 Jan 15;17(2):269-81. [Content Brief]
[13]. Cristina Medina-Trillo, et al. Hypo- and hypermorphic FOXC1 mutations in dominant glaucoma: transactivation and phenotypic variability. PLoS One. 2015 Mar 18;10(3):e0119272. [Content Brief]
[14]. Ramsey A Saleem, et al. Structural and functional analyses of disease-causing missense mutations in the forkhead domain of FOXC1. Hum Mol Genet. 2003 Nov 15;12(22):2993-3005. [Content Brief]
[15]. Zhi-Yuan Xu, et al. FOXC1 contributes to microvascular invasion in primary hepatocellular carcinoma via regulating epithelial-mesenchymal transition. Int J Biol Sci. 2012;8(8):1130-41. [Content Brief]
[16]. Tara C Murphy, et al. The wing 2 region of the FOXC1 forkhead domain is necessary for normal DNA-binding and transactivation functions. Invest Ophthalmol Vis Sci. 2004 Aug;45(8):2531-8. [Content Brief]
[17]. Fred B Berry, et al. FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A. Hum Mol Genet. 2008 Feb 15;17(4):490-505. [Content Brief]
[18]. Morteza Seifi, et al. Comparison of Bioinformatics Prediction, Molecular Modeling, and Functional Analyses of FOXC1 Mutations in Patients with Axenfeld-Rieger Syndrome. Hum Mutat. 2017 Feb;38(2):169-179. [Content Brief]
[19]. Fred B Berry, et al. FOXC1 transcriptional regulation is mediated by N- and C-terminal activation domains and contains a phosphorylated transcriptional inhibitory domain. J Biol Chem. 2002 Mar 22;277(12):10292-7. [Content Brief]
[20]. Fred B Berry, et al. Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis. Hum Mol Genet. 2006 Mar 15;15(6):905-19. [Content Brief]
[21]. Fred B Berry, et al. Regulation of FOXC1 stability and transcriptional activity by an epidermal growth factor-activated mitogen-activated protein kinase signaling cascade. J Biol Chem. 2006 Apr 14;281(15):10098-104. [Content Brief]