Forkhead box protein H1

Definition:

Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).

References:

[1]. S Zhou, et al. Characterization of human FAST-1, a TGF beta and activin signal transducer. Mol Cell. 1998 Jul;2(1):121-7. [Content Brief]

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