Forkhead box protein R1

Definition:

Transcription factor which acts as both an activator and a repressor. Activates transcription of a number of genes including the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 which are involved in protection against oxidative stress. Required for normal brain development (By similarity).

References:

[1]. Andressa Mota, et al. FOXR1 regulates stress response pathways and is necessary for proper brain development. PLoS Genet. 2021 Nov 1;17(11):e1009854. [Content Brief]

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