Four and a half LIM domains protein 2

Definition:

May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes.

References:

[1]. C Paul, et al. The LIM-only protein FHL2 is a negative regulator of E4F1. Oncogene. 2006 Sep 7;25(40):5475-84. [Content Brief]

[2]. Yonghua Yang, et al. Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. EMBO J. 2005 Mar 9;24(5):1021-32. [Content Brief]

[3]. Franziska Dierck, et al. The novel cardiac z-disc protein CEFIP regulates cardiomyocyte hypertrophy by modulating calcineurin signaling. J Biol Chem. 2017 Sep 15;292(37):15180-15191. [Content Brief]

[4]. Sharareh Siamakpour-Reihani, et al. The cell migration protein Grb7 associates with transcriptional regulator FHL2 in a Grb7 phosphorylation-dependent manner. J Mol Recognit. 2009 Jan-Feb;22(1):9-17. [Content Brief]

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