Free fatty acid receptor 2 (FFA2)/GPR43

Definition:

Free fatty acid receptor 2 (FFA2)/GPR43 is a 7-transmembrane receptor activated by short-chain fatty acids (SCFAs) produced endogenously during colonic fermentation of dietary fiber by the gut microbiota. FFA2/GPR43 is expressed in various cell types such as adipocytes, pancreatic β-cells and immune cells.

References:

[1]. Anders Højgaard Hansen, et al. Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43). J Med Chem. 2017 Jul 13;60(13):5638-5645. [Content Brief]

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