Fructose-1,6-bisphosphatase 1

Definition:

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.

References:

[1]. Sherley Visinoni, et al. The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity. Diabetes. 2012 May;61(5):1122-32. [Content Brief]

[2]. Benjamin J Lamont, et al. Expression of human fructose-1,6-bisphosphatase in the liver of transgenic mice results in increased glycerol gluconeogenesis. Endocrinology. 2006 Jun;147(6):2764-72. [Content Brief]

[3]. Melkam Kebede, et al. Fructose-1,6-bisphosphatase overexpression in pancreatic beta-cells results in reduced insulin secretion: a new mechanism for fat-induced impairment of beta-cell function. Diabetes. 2008 Jul;57(7):1887-95. [Content Brief]

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