Fructose-1,6-bisphosphatase isozyme 2

Definition:

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.

References:

[1]. Agnieszka Gizak, et al. A novel remitting leukodystrophy associated with a variant in FBP2. Brain Commun. 2021 Mar 11;3(2):fcab036. [Content Brief]

[2]. Marek Zarzycki, et al. Glu 69 is essential for the high sensitivity of muscle fructose-1,6-bisphosphatase inhibition by calcium ions. FEBS Lett. 2007 Apr 3;581(7):1347-50. [Content Brief]

[3]. Agnieszka Gizak, et al. Evolutionary conserved N-terminal region of human muscle fructose 1,6-bisphosphatase regulates its activity and the interaction with aldolase. Proteins. 2008 Jul;72(1):209-16. [Content Brief]

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