FYVE, RhoGEF and PH domain-containing protein 4

Definition:

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity).

References:

[1]. Xian-Ming Chen, et al. Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42. J Biol Chem. 2004 Jul 23;279(30):31671-8. [Content Brief]

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