G-protein coupled bile acid receptor 1

Definition:

Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.

References:

[1]. Yuji Kawamata, et al. A G protein-coupled receptor responsive to bile acids. J Biol Chem. 2003 Mar 14;278(11):9435-40. [Content Brief]

[2]. Takaharu Maruyama, et al. Identification of membrane-type receptor for bile acids (M-BAR). Biochem Biophys Res Commun. 2002 Nov 15;298(5):714-9. [Content Brief]

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