G-protein coupled receptor 135

Definition:

Orphan receptor. Has spontaneous activity for beta-arrestin recruitment. Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization.

References:

[1]. Atsuro Oishi, et al. Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions. Sci Rep. 2017 Aug 21;7(1):8990. [Content Brief]

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