G-protein coupled receptor 143

Definition:

Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport.

References:

[1]. Vanessa M Lopez, et al. L-DOPA is an endogenous ligand for OA1. PLoS Biol. 2008 Sep 30;6(9):e236. [Content Brief]

[2]. M V Schiaffino, et al. Ocular albinism: evidence for a defect in an intracellular signal transduction system. Nat Genet. 1999 Sep;23(1):108-12. [Content Brief]

[3]. Giulio Innamorati, et al. The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor. Pigment Cell Res. 2006 Apr;19(2):125-35. [Content Brief]

[4]. Ilaria Palmisano, et al. The ocular albinism type 1 protein, an intracellular G protein-coupled receptor, regulates melanosome transport in pigment cells. Hum Mol Genet. 2008 Nov 15;17(22):3487-501. [Content Brief]

[5]. Francesca Giordano, et al. The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition. Hum Mol Genet. 2009 Dec 1;18(23):4530-45. [Content Brief]

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