G-protein coupled receptor 4

Definition:

Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA12/GNA13/Rho pathways. Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway. In the brain may mediate central respiratory sensitivity to CO(2)H(+) (By similarity).

References:

[1]. Marie-Gabrielle Ludwig, et al. Proton-sensing G-protein-coupled receptors. Nature. 2003 Sep 4;425(6953):93-8. [Content Brief]

[2]. Aishe Chen, et al. Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway. PLoS One. 2011;6(11):e27586. [Content Brief]

[3]. Masayuki Tobo, et al. Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms. Cell Signal. 2007 Aug;19(8):1745-53. [Content Brief]

[4]. Elizabeth A Krewson, et al. The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells. iScience. 2020 Feb 21;23(2):100848. [Content Brief]

[5]. Jin-Peng Liu, et al. Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways. Pharmacol Res. 2010 Jun;61(6):499-505. [Content Brief]

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