Galanin receptor type 2

Definition:

Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).

References:

[1]. B Borowsky, et al. Cloning and characterization of the human galanin GALR2 receptor. Peptides. 1998;19(10):1771-81. [Content Brief]

[2]. Michel Guipponi, et al. Galanin pathogenic mutations in temporal lobe epilepsy. Hum Mol Genet. 2015 Jun 1;24(11):3082-91. [Content Brief]

[3]. B T Bloomquist, et al. Cloning and expression of the human galanin receptor GalR2. Biochem Biophys Res Commun. 1998 Feb 13;243(2):474-9. [Content Brief]

[4]. L F Kolakowski Jr, et al. Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3. J Neurochem. 1998 Dec;71(6):2239-51. [Content Brief]

[5]. Dong-Kyu Kim, et al. Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III. Endocrinology. 2014 May;155(5):1864-73. [Content Brief]

[6]. Z Fathi, et al. Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor. Brain Res Mol Brain Res. 1998 Jul 15;58(1-2):156-69. [Content Brief]

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