Gamma-taxilin

Definition:

May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression.

References:

[1]. Vionnie W C Yu, et al. FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice. J Cell Biol. 2005 May 23;169(4):591-601. [Content Brief]

[2]. Kejun Du, et al. Over-expression and siRNA of a novel environmental lipopolysaccharide-responding gene on the cell cycle of the human hepatoma-derived cell line HepG2. Toxicology. 2008 Jan 20;243(3):303-10. [Content Brief]

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