Germinal-center associated nuclear protein

Definition

[Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations.; [Isoform MCM3AP]: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations.

References:

[1]. Y Takei, et al. MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3. EMBO Rep. 2001 Feb;2(2):119-23. [Content Brief]

[2]. Vihandha O Wickramasinghe, et al. mRNA export from mammalian cell nuclei is dependent on GANP. Curr Biol. 2010 Jan 12;20(1):25-31. [Content Brief]

[3]. David Umlauf, et al. The human TREX-2 complex is stably associated with the nuclear pore basket. J Cell Sci. 2013 Jun 15;126(Pt 12):2656-67. [Content Brief]

[4]. Yoshinori Takei, et al. The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3. J Biol Chem. 2002 Nov 8;277(45):43121-5. [Content Brief]

[5]. Shailendra Kumar Singh, et al. GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy. Nat Commun. 2013;4:1830. [Content Brief]

[6]. Divyang Jani, et al. Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export. Nucleic Acids Res. 2012 May;40(10):4562-73. [Content Brief]

[7]. Nobukazu Okamoto, et al. Germinal center-associated nuclear protein (GANP) is involved in mRNA export of Shugoshin-1 required for centromere cohesion and in sister-chromatid exchange. Genes Cells. 2010 May;15(5):471-84. [Content Brief]

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