GK regulatory protein (GKRP)

Definition:

GK regulatory protein (GKRP) is located mainly in hepatocytes with an excess ratio to Glucokinase (Glucokinase, GK). GKRP allosterically regulates the activity and subcellular localization of GK. GKRP inhibits and sequesters GK into the nucleus of hepatocytes and releases GK into the cytoplasm in response to glucose concentration.

References:

[1]. Jung Min Choi, et al. Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10171-6. [Content Brief]

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