Glucocorticoid receptor
Definition:
References:
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[1]. Evangelia Charmandari, et al. A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity. J Clin Endocrinol Metab. 2005 Jun;90(6):3696-705. [Content Brief]
[2]. C J Fryer, et al. Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex. Nature. 1998 May 7;393(6680):88-91. [Content Brief]
[3]. Bo He, et al. Human Glucocorticoid Receptor β Regulates Gluconeogenesis and Inflammation in Mouse Liver. Mol Cell Biol. 2015 Dec 28;36(5):714-30. [Content Brief]
[4]. Géraldine Vitellius, et al. Three Novel Heterozygous Point Mutations of NR3C1 Causing Glucocorticoid Resistance. Hum Mutat. 2016 Aug;37(8):794-803. [Content Brief]
[5]. M R Yudt, et al. Molecular identification and characterization of a and b forms of the glucocorticoid receptor. Mol Endocrinol. 2001 Jul;15(7):1093-103. [Content Brief]
[6]. Ingrid K Bender, et al. Determinants of the heightened activity of glucocorticoid receptor translational isoforms. Mol Endocrinol. 2013 Sep;27(9):1577-87. [Content Brief]
[7]. C M Bamberger, et al. Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans. J Clin Invest. 1995 Jun;95(6):2435-41. [Content Brief]
[8]. I Wu, et al. Selective glucocorticoid receptor translational isoforms reveal glucocorticoid-induced apoptotic transcriptomes. Cell Death Dis. 2013 Jan 10;4(1):e453. [Content Brief]
[9]. R H Oakley, et al. The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function. J Biol Chem. 1996 Apr 19;271(16):9550-9. [Content Brief]
[10]. Tomoshige Kino, et al. Glucocorticoid receptor (GR) beta has intrinsic, GRalpha-independent transcriptional activity. Biochem Biophys Res Commun. 2009 Apr 17;381(4):671-5. [Content Brief]
[11]. Laura C Matthews, et al. Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5479-84. [Content Brief]
[12]. Nick Z Lu, et al. Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes. Mol Cell. 2005 Apr 29;18(3):331-42. [Content Brief]
[13]. Hana Cho, et al. Glucocorticoid receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1540-9. [Content Brief]
[14]. Yoshinori Taniguchi, et al. Glucocorticoid receptor-beta and receptor-gamma exert dominant negative effect on gene repression but not on gene induction. Endocrinology. 2010 Jul;151(7):3204-13. [Content Brief]
[15]. Anna-Maria G Psarra, et al. Glucocorticoids induce mitochondrial gene transcription in HepG2 cells: role of the mitochondrial glucocorticoid receptor. Biochim Biophys Acta. 2011 Oct;1813(10):1814-21. [Content Brief]
[16]. P de Lange, et al. Expression in hematological malignancies of a glucocorticoid receptor splice variant that augments glucocorticoid receptor-mediated effects in transfected cells. Cancer Res. 2001 May 15;61(10):3937-41. [Content Brief]
[17]. Evangelia Charmandari, et al. A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance. J Clin Endocrinol Metab. 2007 Oct;92(10):3986-90. [Content Brief]
[18]. Nancy Nader, et al. Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications. FASEB J. 2009 May;23(5):1572-83. [Content Brief]
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