Glucokinase regulatory protein

Definition:

Regulates glucokinase (GCK) by forming an inactive complex with this enzyme. Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.

References:

[1]. Alexander Pautsch, et al. Crystal structure of glucokinase regulatory protein. Biochemistry. 2013 May 21;52(20):3523-31. [Content Brief]

[2]. N de la Iglesia, et al. Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase. FEBS Lett. 1999 Aug 6;456(2):332-8. [Content Brief]

[3]. Jung Min Choi, et al. Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10171-6. [Content Brief]

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