Glucose-6-phosphate 1-dehydrogenase

Definition:

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.

References:

[1]. Marie Warny, et al. Severe G6PD Deficiency Due to a New Missense Mutation in an Infant of Northern European Descent. J Pediatr Hematol Oncol. 2015 Nov;37(8):e497-9. [Content Brief]

[2]. Yi-Ping Wang, et al. Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. EMBO J. 2014 Jun 17;33(12):1304-20. [Content Brief]

[3]. Masayo Kotaka, et al. Structural studies of glucose-6-phosphate and NADP+ binding to human glucose-6-phosphate dehydrogenase. Acta Crystallogr D Biol Crystallogr. 2005 May;61(Pt 5):495-504. [Content Brief]

[4]. U Benatti, et al. Glucose 6-phosphate dehydrogenase activity in membranes of erythrocytes from normal individuals and subjects with Mediterranean G6PD deficiency. Biochem Biophys Res Commun. 1978 Dec 29;85(4):1318-24. [Content Brief]

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