Glutathione Peroxidase 4 (GPX4)

Definition:

Glutathione peroxidase 4 (Gpx4) is 1 of 8 known glutathione peroxidases in mammals and Gpx4 is unique among Gpx isoforms as it is the only enzyme capable of reducing esterified oxidized fatty acids and cholesterol hydroperoxides.

References:

[1]. Conrad M, Friedmann Angeli JP. Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it? Mol Cell Oncol. 2015 Jan 30;2(3):e995047. [Content Brief]

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