Glutathione-specific gamma-glutamylcyclotransferase 1

Definition:

Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos.

References:

[1]. Zhikai Chi, et al. Botch promotes neurogenesis by antagonizing Notch. Dev Cell. 2012 Apr 17;22(4):707-20. [Content Brief]

[2]. Amandeep Kaur, et al. ChaC2, an Enzyme for Slow Turnover of Cytosolic Glutathione. J Biol Chem. 2017 Jan 13;292(2):638-651. [Content Brief]

[3]. Imran N Mungrue, et al. CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade. J Immunol. 2009 Jan 1;182(1):466-76. [Content Brief]

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